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Effects of Xuebijing Injection for Patients With Sepsis-induced Acute Kidney Injury After Wenchuan Earthquake

Qin Yuxi, PhD; Hanlai Zhang;Yu Baili, PhD; Shihua Shi

Context • Earthquakes are devastating disasters that have claimed countless lives in the past, partially owing to the danger of direct and indirect injuries to vital organs. In the deadly earthquake that occurred in Sichuan Province of China on May 12, 2008, some victims suffered from severe damage to multiple organs and tissue and developed sepsis, a systematic inflammatory reaction resulting from infection and trauma. Xuebijing injection (CCXG) could beneficial for improvement of clinical symptoms in those patients, but no research has yet examined its potential.

Objective • The study intended to investigate whether a combination of conventional treatment and CCXG was superior to conventional treatment alone, or the control group (CG), in the treatment of clinical symptoms in patients with sepsis-induced acute kidney injury (AKI).

Design • The study retrospectively analyzed the medical records of individuals who were injured in an earthquake that occurred in the Sichuan Province of China on May 12, 2008, and who developed AKI.

Setting • The study took place in the hospital associated with Chengdu University of Traditional Chinese Medicine (Chengdu, Sichuan, China).

Participants • Participants were 55 injured individuals who were treated at the hospital. The CG included 27 patients and the CCXG group included 28 patients.

Intervention • Both the intervention group (CCXG group) and the CG received the conventional treatment. The CCXG group was also given intravenous drips containing 100 mL of CCXG. The CG was given 100 mL of a 10% normal saline injection in addition to conventional treatment. Both received the treatments within 30 to 40 min, 3 ×/d.

Outcome Measures • Blood urea nitrogen (BUN), creatine phosphate kinase (CPK), serum creatinine (Cr), interleukin 1 (IL-1), and interleukin 6 (IL-6) were measured before treatment and on days 5, 7, and 10 after treatment.

Results • The levels of CPK, BUN, Cr, and IL-6 for both groups were significantly lower than at baseline on day 5, 7, and 10 after treatment (P < .05). The levels of the CCXG group were significantly lower than those of the CG group on days 5, 7, and 10 (P < .05).

Conclusions • As a supplement, CCXG is an effective method of improving the clinical symptoms of sepsis-induced AKI.

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